Toxicological studies on a novel phytase expressed from synthetic genes in Aspergillus oryzae.

@article{Lichtenberg2011ToxicologicalSO,
  title={Toxicological studies on a novel phytase expressed from synthetic genes in Aspergillus oryzae.},
  author={Jens Lichtenberg and P B Pedersen and S G Elvig-Joergensen and Lars K. Skov and Catherine L. Olsen and L V Glitsoe},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2011},
  volume={60 3},
  pages={401-10}
}
Phytases are widely used as feed additives for monogastric animals, which cannot easily utilise the phosphorus bound in phytate (myo-inositol hexakisphosphate). The current study presents a safety evaluation of a 6-phytase produced by an Aspergillus oryzae strain expressing two synthetic genes, both mimicking a phytase gene from a Citrobacter braakii strain. Oral administration of the phytase preparation to rats at a dose level of 0.86 g total organic solids/kg body weight/day for 13 weeks did… CONTINUE READING
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