Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes.

Abstract

Changes in enzyme activity due to induction by chemicals is an important property that can determine the type of response seen in tissues exposed to environmental chemicals. Two major types of response, acute irreversible liver cell injury or death (necrosis) and long-term cancer induction, are discussed in terms of their modulation by enzyme induction… (More)

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