Toxicological significance of covalently-bound residues.

  title={Toxicological significance of covalently-bound residues.},
  author={Alvaro Rico and Viviane Burgat-Sacaze},
  journal={Food additives and contaminants},
  volume={1 2},
Bound residues may be defined in terms of the nonextractable radioactivity which persists in tissues after administration of radiolabelled compounds to an organism. This fraction is found to contain natural endogenous compounds resulting from incorporation of degradation products of the administered substance into intermediary metabolites (amino acids, carbohydrates etc.). However, 'new' compounds are also found which arise from covalent binding of the administered substance or its metabolites… CONTINUE READING