Toxicological safety evaluation of gadobenate dimeglumine 0.5 M solution for injection (MultiHance), a new magnetic resonance imaging contrast medium.

@article{Morisetti1999ToxicologicalSE,
  title={Toxicological safety evaluation of gadobenate dimeglumine 0.5 M solution for injection (MultiHance), a new magnetic resonance imaging contrast medium.},
  author={Alberto Morisetti and Simona Bussi and Piero Tirone and Christoph de Ha{\"e}n},
  journal={Journal of computer assisted tomography},
  year={1999},
  volume={23 Suppl 1},
  pages={
          S207-17
        }
}
OBJECTIVE To support the clinical use of gadobenate dimeglumine for injection as an intravascular magnetic resonance imaging contrast medium through an extensive battery of toxicological safety studies. METHODS Single and multiple dose toxicity, reproduction and mutagenicity assessments were carried out in rodents and non-rodents. RESULTS Initial adverse clinical signs in monkeys were associated with a systemic exposure 34 times higher than that found in humans after 0.1 mmol/kg gadobenate… 
Toxicological assessment of gadolinium release from contrast media.
  • S. Bussi, X. Fouillet, A. Morisetti
  • Medicine, Biology
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2007
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