Toxicological profile of orally administered 1,6‐hexane diamine in the rat

@article{Johannsen1987ToxicologicalPO,
  title={Toxicological profile of orally administered 1,6‐hexane diamine in the rat},
  author={Frederick R. Johannsen and George J. Levinskas},
  journal={Journal of Applied Toxicology},
  year={1987},
  volume={7}
}
The industrial chemical 1,6‐Hexane Diamine, or hexamethylenediamine (HMD), has an acute oral LD50 of 980 mg kg−1 in rats. Dietary administration of HMD to groups of rats for 3 months at dosages of 0, 50, 150, and 500 mg kg−1 resulted in a modest retardation in weight gain at the two higher test levels. No other obvious signs of toxicity or changes in the peripheral blood picture or selected clinical pathology parameters were found at any test level throughout the study. Evaluation of absolute… 
Inhalation Toxicity of 1,6-Hexanediamine Dihydrochloride in F344/N Rats and B6C3F1 Mice
TLDR
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NTP technical report on the toxicity studies of 1,6-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice.
  • C. Hébert
  • Biology, Medicine
    Toxicity report series
  • 1993
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Development of a chronic inhalation reference value for hexamethylenediamine using an exposure model based on the dihydrochloride salt
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A chronic inhalation Reference Value (ReV) for hexamethylenediamine (HMDA) is developed based on respiratory effects identified in an animal study and the critical effect identified for the most sensitive species was hyaline degeneration in the olfactory epithelium in mice.
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The residual agents and the specific crosslinks present in DSCs as a consequence of processing and the crosslinking agents used give rise to differences in direct release of products and in sensitivity to hydrolysis and enzymatic breakdown.
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The aim of this study was to develop a more sensitive cytotoxicity test system for biomaterials, using methylcellulose as a culture gel, mixed with human fibroblasts, and it is concluded that the test system is extremely useful to test materials which are suspected of primary and/or secondary cytotoxic effects.
Tissue Interactions with Dermal Sheep Collagen Implants: A Transmission Electron Microscopical Evaluation
Tissue interactions with discs of dermal sheep collagen (DSC), subcutaneously implanted in rats, were evaluated using transmission electron microscopy. DSC cross-linked with hexamethylenediisocyanate
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This in vivo study confirms in vitro results, in that TC-pretreatment of crosslinked DSC's resulted in the marked reduction or elimination of cytotoxic effects, such as increased cell infiltration, a deviant neutrophil-morphology, lipid formation and cell death.
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