Toxicological profile of orally administered 1,6‐hexane diamine in the rat

  title={Toxicological profile of orally administered 1,6‐hexane diamine in the rat},
  author={Frederick R. Johannsen and George J. Levinskas},
  journal={Journal of Applied Toxicology},
The industrial chemical 1,6‐Hexane Diamine, or hexamethylenediamine (HMD), has an acute oral LD50 of 980 mg kg−1 in rats. Dietary administration of HMD to groups of rats for 3 months at dosages of 0, 50, 150, and 500 mg kg−1 resulted in a modest retardation in weight gain at the two higher test levels. No other obvious signs of toxicity or changes in the peripheral blood picture or selected clinical pathology parameters were found at any test level throughout the study. Evaluation of absolute… 
Inhalation Toxicity of 1,6-Hexanediamine Dihydrochloride in F344/N Rats and B6C3F1 Mice
The toxicity of HDDC to rats and mice was a result of the irritant properties of the chemical, was limited primarily to the nasal passages and upper airways, and was consistent with the effects of other irritant chemicals administered by inhalation.
NTP technical report on the toxicity studies of 1,6-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice.
  • C. Hébert
  • Biology, Medicine
    Toxicity report series
  • 1993
In rats and mice, histopathologic lesions that were considered related to chemical exposure included inflammation and necrosis of laryngeal epithelium as well as focal inflammation and ulceration of the respiratory and olfactory nasal mucosa in the 2 highest exposure groups.
Toxicity of Hexamethylenediamine (HMDA)
Hexamethylendiamine (HMDA; CAS No. 124-09-4; 6055-52-3 for the dihydrochloride salt) is moderately toxic following acute doses/exposures with oral lethal doses in rats ranging from 750 to 1500 mg/kg.
Development of a chronic inhalation reference value for hexamethylenediamine using an exposure model based on the dihydrochloride salt
A chronic inhalation Reference Value (ReV) for hexamethylenediamine (HMDA) is developed based on respiratory effects identified in an animal study and the critical effect identified for the most sensitive species was hyaline degeneration in the olfactory epithelium in mice.
A two-generation reproduction study in rats receiving diets containing hexamethylenediamine.
Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern.
Relations between in vitro cytotoxicity and crosslinked dermal sheep collagens.
The residual agents and the specific crosslinks present in DSCs as a consequence of processing and the crosslinking agents used give rise to differences in direct release of products and in sensitivity to hydrolysis and enzymatic breakdown.
Methylcellulose cell culture as a new cytotoxicity test system for biomaterials
The aim of this study was to develop a more sensitive cytotoxicity test system for biomaterials, using methylcellulose as a culture gel, mixed with human fibroblasts, and it is concluded that the test system is extremely useful to test materials which are suspected of primary and/or secondary cytotoxic effects.
Tissue Interactions with Dermal Sheep Collagen Implants: A Transmission Electron Microscopical Evaluation
Tissue interactions with discs of dermal sheep collagen (DSC), subcutaneously implanted in rats, were evaluated using transmission electron microscopy. DSC cross-linked with hexamethylenediisocyanate
In vivo interactions with (tissue culture pretreated) dermal sheep collagen
This in vivo study confirms in vitro results, in that TC-pretreatment of crosslinked DSC's resulted in the marked reduction or elimination of cytotoxic effects, such as increased cell infiltration, a deviant neutrophil-morphology, lipid formation and cell death.


Estimation of acute oral toxicity in rates by determination of the approximate lethal dose rather than the LD50
The approximiate lethal dose (ALD) to rats following oral administration of nine chemicals was determined and the category indicated by the ALD was identical with the category determined in the more extensive LD50 studies.
The construction of the scales and nomographs is described and their use is illustrated by an example.
Nonparametric Statistics for the Behavioral Sciences.
This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others. The original structure is retained, and the book continues to serve as a combined