Corpus ID: 230510456

Toxicological characteristics of the antitussive preparation glaucine

  title={Toxicological characteristics of the antitussive preparation glaucine},
  author={Mironova Mi and Arzamastsev Ev and Bortnikova Vv and Krepkova Lv},
  journal={Farmakologiia i toksikologiia},
  • Mironova Mi, Arzamastsev Ev, +1 author Krepkova Lv
  • Published 1983
  • Chemistry
  • Farmakologiia i toksikologiia
  • A toxicological study was made of the antitussive drug glaucinee hydrochloride, an alkaloid of the isoquinoline series (4,5,7,8-tetramethoxyaporphine hydrochloride) isolated from Glaucinum flavum Crantz. of the Papaveraceae family. Upon a single intraperitoneal injection to different laboratory animals the LD50 was found to be equal to 150--180 mg/kg whereas upon intragastric administration, to 510--620 mg/kg. Under the conditions of chronic experiments (intragastric administration to rats in… CONTINUE READING