Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes.

@article{Mirshafiee2018ToxicologicalPO,
  title={Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes.},
  author={Vahid Mirshafiee and B. Sun and C. Chang and Y. Liao and Wen Jiang and Jinhong Jiang and X. Liu and X. Wang and T. Xia and A. Nel},
  journal={ACS nano},
  year={2018},
  volume={12 4},
  pages={
          3836-3852
        }
}
The liver and the mononuclear phagocyte system are a frequent target for engineered nanomaterials, either as a result of particle uptake and spread from primary exposure sites or systemic administration of therapeutic and imaging nanoparticles. In this study, we performed a comparative analysis of the toxicological impact of 29 metal oxide nanoparticles (NPs), some commonly used in consumer products, in transformed or primary Kupffer cells (KCs) and hepatocytes. We not only observed differences… Expand
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