Toxicologic studies of antitumor amino acid derivatives in mice and rats.

@article{Fukushima1974ToxicologicSO,
  title={Toxicologic studies of antitumor amino acid derivatives in mice and rats.},
  author={K. Fukushima and Sogen Itoh and S. Toyoshima},
  journal={The Keio Journal of Medicine},
  year={1974},
  volume={23},
  pages={191-204}
}
  • K. Fukushima, Sogen Itoh, S. Toyoshima
  • Published 1974
  • Medicine
  • The Keio Journal of Medicine
  • Toxicity of five antitumor amino acid derivatives, N-β-naphthalenesulfonyl-DL-tryptophan(A-91), β-naphthylaminomethyl-γ-aminobutyric acid (A-144), N-ethylcarbaminomethyl-L-isoleucine(A-145), N-9-fluorenylacetyl-Lphenylalanine(A-192), and N-propionyl-L-valine(A-195) were studied in mice and rats. These amino acid derivatives (A-A derivatives), with the exception of A-192, were less toxic in mice and rats administered single intraperitoneally (ip) and orally(po).In repeated-dose studies with the… CONTINUE READING

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