Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration.

@article{Bottein2011ToxicokineticsOT,
  title={Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration.},
  author={Marie-Yasmine Dechraoui Bottein and Zhihong Wang and John S. Ramsdell},
  journal={Toxicology},
  year={2011},
  volume={284 1-3},
  pages={1-6}
}
Ciguatoxins are voltage-gated selective algal toxins responsible for ciguatera fish poisoning. In this study we evaluate the toxicokinetics of one of the most common ciguatoxins found in the Pacific, the P-CTX-1, in rat after an oral or intraperitoneal (ip) dose of 0.26 μg/kg body weight. We report levels of ciguatoxin activity assessed over time in blood, urine and feces, and at 4 days in liver, muscle and brain, using the functional in vitro N2A cytotoxicity assay. Following exposure, the… CONTINUE READING

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