Toxicokinetics of riddelliine, a carcinogenic pyrrolizidine alkaloid, and metabolites in rats and mice.

@article{Williams2002ToxicokineticsOR,
  title={Toxicokinetics of riddelliine, a carcinogenic pyrrolizidine alkaloid, and metabolites in rats and mice.},
  author={L. David Williams and Ming W. Chou and Jian Yan and John Fariselli Young and P. C. Y. Chan and Daniel R. Doerge},
  journal={Toxicology and applied pharmacology},
  year={2002},
  volume={182 2},
  pages={98-104}
}
Riddelliine is a representative pyrrolizidine alkaloid, a class of naturally occurring toxic phytochemicals present in plant species worldwide. Human exposure to pyrrolizidine alkaloids occurs through consumption of herbal dietary supplements, including comfrey, and through contaminated livestock products (e.g., milk). A recently completed 2-year bioassay of riddelliine carcinogenicity showed that male and female rats and male mice, but not female mice, developed liver tumors. The… CONTINUE READING
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