Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats.

  title={Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats.},
  author={Daniel R. Doerge and John Fariselli Young and Lea P. McDaniel and Nathan C. Twaddle and Mona I. Churchwell},
  journal={Toxicology and applied pharmacology},
  volume={208 3},
Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxic mechanisms, particularly toxicokinetics and bioavailability. This study compares the toxicokinetics of AA and its epoxide metabolite, glycidamide (GA), in serum and tissues of male and female F344 rats following… CONTINUE READING
30 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…