Toxicokinetics and biotransformation of 3-(4-methylbenzylidene)camphor in rats after oral administration.

@article{Vlkel2006ToxicokineticsAB,
  title={Toxicokinetics and biotransformation of 3-(4-methylbenzylidene)camphor in rats after oral administration.},
  author={Wolfgang V{\"o}lkel and Thomas Colnot and Ute M D Schauer and Thomas H Broschard and Wolfgang Dekant},
  journal={Toxicology and applied pharmacology},
  year={2006},
  volume={216 2},
  pages={331-8}
}
3-(4-Methylbenzylidene)camphor (4-MBC) is an UV-filter frequently used in sunscreens and cosmetics. Equivocal findings in some screening tests for hormonal activity initiated a discussion on a possible weak estrogenicity of 4-MBC. In this study, the toxicokinetics and biotransformation of 4-MBC were characterized in rats after oral administration. Male and female Sprague-Dawley rats (n = 3 per group) were administered single oral doses of 25 or 250 mg/kg bw of 4-MBC in corn oil. Metabolites… CONTINUE READING

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