Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact

@article{BritodaCosta2020ToxicokineticsAT,
  title={Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact},
  author={Andreia Machado Brito-da-Costa and Diana Dias-da-Silva and Nelson G M Gomes and Ricardo Jorge Dinis-Oliveira and {\'A}urea Madureira-Carvalho},
  journal={Pharmaceuticals},
  year={2020},
  volume={13}
}
Ayahuasca is a hallucinogenic botanical beverage originally used by indigenous Amazonian tribes in religious ceremonies and therapeutic practices. While ethnobotanical surveys still indicate its spiritual and medicinal uses, consumption of ayahuasca has been progressively related with a recreational purpose, particularly in Western societies. The ayahuasca aqueous concoction is typically prepared from the leaves of the N,N-dimethyltryptamine (DMT)-containing Psychotria viridis, and the stem and… Expand

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References

SHOWING 1-10 OF 258 REFERENCES
Toxicological Aspects and Determination of the Main Components of Ayahuasca: A Critical Review
TLDR
This paper will perform a comprehensive and critical review on the analytical methods available for their determination in biological and non-biological specimens, with special focus on instrumental developments and sample preparation approaches. Expand
Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca.
TLDR
The present results show the existence in humans of alternative metabolic routes for DMT other than biotransformation by MAO and that O-demethylation plus conjugation is an important but probably not the only metabolic route for the harmala alkaloids in humans. Expand
Developments in harmine pharmacology — Implications for ayahuasca use and drug-dependence treatment
TLDR
The pharmacological mechanisms for the putative reduction in recidivism to alcohol and cocaine misuse are suggested and inhibition of dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) and the dopamine transporter is suggested. Expand
Pharmacokinetics of Hoasca alkaloids in healthy humans.
TLDR
N,N-Dimethyltryptamine, harmine, harmaline and tetrahydroharmine are the characteristic alkaloids found in Amazonian sacraments known as hoasca, ayahuasca, and yajè and little is known of their pharmacokinetics. Expand
Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca.
TLDR
The one-step extraction method for DMT and the protein precipitation method for the three harmala alkaloid afford rapid, sensitive, and quantitative analyses of these alkaloids with minimal analyte loss. Expand
“Ayahuasca,” the South American hallucinogenic drink: An ethnobotanical and chemical investigation
TLDR
Harmine, Harmaline, Tetrahydroharmine and Dimethyltryptamine have been found in the Ayahuasca drink. Expand
Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and beta-carboline constituents of ayahuasca.
TLDR
The levels of DMT and beta-carbolines found in the ayahuasca samples examined in the present study were an order of magnitude greater than the levels reported in a previous study, which indicated that their effects in combination are additive, rather than synergistic or antagonistic. Expand
A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract.
TLDR
This is, to the authors' knowledge, the first case of P. harmala intoxication corroborated by toxicological findings, and it is reported that the patient had no prior history of intoxication following intentional ingestion of the drug. Expand
Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges.
  • D. Mckenna
  • Political Science, Chemistry
  • Pharmacology & therapeutics
  • 2004
TLDR
Because of ayahuasca's ill-defined legal status and variable botanical and chemical composition, clinical investigations in the United States, ideally under an approved Investigational New Drug (IND) protocol, are complicated by both regulatory and methodological issues. Expand
Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca: A Comparative Study With d-Amphetamine
TLDR
In conclusion, ayahuasca displayed moderate sympathomimetic effects, significant neuroendocrine stimulation, and a time-dependent modulatory effect on cell-mediated immunity. Expand
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