Toxicogenomics of resveratrol in rat liver.

  title={Toxicogenomics of resveratrol in rat liver.},
  author={Vidya Hebbar and Guoxiang Shen and Rong Hu and B Kim and Chi Lan Chen and Peter J Korytko and James A. Crowell and Barry S. Levine and A-N Tony Kong},
  journal={Life sciences},
  volume={76 20},
Resveratrol, a polyphenolic compound found in grape skin and peanuts has been shown to prevent many diseases including cardiovascular diseases and cancer. To better understand resveratrol's potential in vivo toxicity, we studied the dose response using cDNA stress arrays coupled with drug metabolizing enzymatic (DME) assays to investigate the expression of stress-responsive genes and Phase I and II detoxifying enzymes in rat livers. Male and female CD rats were treated with high doses of… CONTINUE READING


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