Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity.

@article{Hollins2007ToxicogenomicsOD,
  title={Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity.},
  author={Andrew J. Hollins and Yadollah Omidi and Ibrahim Fadil Benter and Saghir Akhtar},
  journal={Journal of drug targeting},
  year={2007},
  volume={15 1},
  pages={83-8}
}
Synthetic siRNAs are typically formulated with drug delivery systems (DDS) that improve cellular uptake for optimal gene silencing activity. Here, we show that two PAMAM dendrimer DDS, differing only in their structural architecture, elicit many different gene expression changes in human cells including opposing effects on the expression of epidermal growth factor receptor (EGFR), a gene targeted for silencing by siRNA. Despite providing similar improvements in siRNA uptake, these two… CONTINUE READING

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