Toxicogenomic assessment of liver responses following subchronic exposure to furan in Fischer F344 rats

@inproceedings{Dong2015ToxicogenomicAO,
  title={Toxicogenomic assessment of liver responses following subchronic exposure to furan in Fischer F344 rats},
  author={Hongyan Dong and Santokh Singh Gill and Ivan H. A. Curran and Andrew Lee Williams and Byron Kuo and Michael G Wade and Carole Yauk},
  booktitle={Archives of Toxicology},
  year={2015}
}
Abstract Furan is a widely used industrial chemical and a contaminant in heated foods. Chronic furan exposure causes cholangiocarcinoma and hepatocellular tumors in rats at doses of 2 mg/kg bw/day or greater, with gender differences in frequency and severity. The hepatic transcriptional alterations induced by low doses of furan (doses below those previously tested for induction of liver tumors) and the potential mechanisms underlying gender differences are largely unexplored. We used DNA… CONTINUE READING
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Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure.

  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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