Toxicogenomic analysis identifies the apoptotic pathway as the main cause of hepatotoxicity induced by tributyltin.

@article{Zhou2016ToxicogenomicAI,
  title={Toxicogenomic analysis identifies the apoptotic pathway as the main cause of hepatotoxicity induced by tributyltin.},
  author={Mi Zhou and Mei Feng and Ling-ling Fu and Lin-Dan Ji and Jin-shun Zhao and Jin Xu},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2016},
  volume={97},
  pages={
          316-326
        }
}
Tributyltin (TBT) is one of the most widely used organotin biocides, which has severe endocrine-disrupting effects on marine species and mammals. Given that TBT accumulates at higher levels in the liver than in any other organ, and it acts mainly as a hepatotoxic agent, it is important to clearly delineate the hepatotoxicity of TBT. However, most of the available studies on TBT have focused on observations at the cellular level, while studies at the level of genes and proteins are limited… CONTINUE READING
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