Toxicogenetic and antioxidant activities of isopentyl ferulate

  title={Toxicogenetic and antioxidant activities of isopentyl ferulate},
  author={Marcela Rosado Drumond Taimo and A. A. A. Junior and A. L. G. J{\'u}nior and A. Mata and M. O. B. D. Alencar and M. Islam and M. F. C. J. Paz and H. M. L. Rolim and M. G. F. Medeiros and A. A. Melo-Cavalcante},
  journal={African Journal of Pharmacy and Pharmacology},
This study aims to determine the toxicity, genotoxicity and antioxidative defense capacities of isopentanyl ferulate (IF), an ester derivative of ferulic acid (FA). Therefore, albino mice (25-30 g) were treated with 1000 to 3000 mg/kg orally (p.o.) and intraperitoneally (i.p.) to determine median lethal dose (LD50), biochemical and hematological parameters, motor coordination and genotoxic activity by comet assay. In addition, oxidative defense was assessed in Saccharomyces cerevisiae with one… Expand
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