Toxicity of toxaphene in the rat and beagle dog.

  title={Toxicity of toxaphene in the rat and beagle dog.},
  author={I M Chu and Danielle Villeneuve and Cheng-wen Sun and V E Secours and Bryan Procter and Edwin Paterson Arnold and Deborah J. Clegg and Lou Reynolds and Victor E. O. Valli},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={7 3},
Residues of the insecticidal mixture, toxaphene, have been found in Great Lakes fish. The purpose of the present study was to assess the subchronic toxicity of toxaphene in the rat and beagle dog. In the rat study, groups of 10 male and 10 female animals were fed diets containing 0, 4, 20, 100, or 500 ppm of the test compound for 13 weeks. No clinical signs of toxicity or spontaneous deaths were observed. Toxaphene treatment up to 500 ppm had no effects on weight gain or food consumption. The… CONTINUE READING