Toxicity of statins on rat skeletal muscle mitochondria

@article{Kaufmann2006ToxicityOS,
  title={Toxicity of statins on rat skeletal muscle mitochondria},
  author={Priska Kaufmann and Michael T{\"o}r{\"o}k and Anja Zahno and Katri Maria Waldhauser and Karin Brecht and Stephan Kr{\"a}henb{\"u}hl},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2006},
  volume={63},
  pages={2415-2425}
}
We investigated mitochondrial toxicity of four lipophilic stains (cerivastatin, fluvastatin, atorvastatin, simvastatin) and one hydrophilic statin (pravastatin). In L6 cells (rat skeletal muscle cell line), the four lipophilic statins (100 μmol/l) induced death in 27–49% of the cells. Pravastatin was not toxic up to 1 mmol/l. Cerivastatin, fluvastatin and atorvastatin (100 μmol/l) decreased the mitochondrial membrane potential by 49–65%, whereas simvastatin and pravastatin were less toxic. In… CONTINUE READING