Toxicity of silica nanoparticles depends on size, dose, and cell type.

  title={Toxicity of silica nanoparticles depends on size, dose, and cell type.},
  author={In-Yong Kim and Elizabeth Joachim and Hyungsoo Choi and Kyekyoon Kevin Kim},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  volume={11 6},
UNLABELLED Monodisperse spherical silica nanoparticles (SNPs) with diameters of 20-200 nm were employed to study size, dose, and cell-type dependent cytotoxicity in A549 and HepG2 epithelial cells and NIH/3T3 fibroblasts. These uniform SNPs of precisely controlled sizes eliminated uncertainties arising from mixed sizes, and uniquely allowed the probing of effects entirely size-dependent. Cell viability, membrane disruption, oxidative stress, and cellular uptake were studied. The extent and… CONTINUE READING
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