Toxicity of short-term administration of cannabinoids to rhesus monkeys.

@article{Rosenkrantz1981ToxicityOS,
  title={Toxicity of short-term administration of cannabinoids to rhesus monkeys.},
  author={H. Rosenkrantz and R. Fleischman and R. Grant},
  journal={Toxicology and applied pharmacology},
  year={1981},
  volume={58 1},
  pages={
          118-31
        }
}
Abstract Because of potential use as therapeutic agents, additional toxicologic studies on pure cannabinoids and cannabis extracts were conducted. Monkeys received a single iv dose of cannabidiol (CBD) or cannabichromene (CBCH) as an aqueous emulsion and LD50s were 212 and 270 mg/kg, respectively. The larger doses of CBD elicited tremors, convulsions, hypopnea, bradycardia, and cardiac failure. Survivors from smaller doses recovered in 1–3 days and liver weights increased 19–142%. CBCH evoked a… Expand
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