Toxicity of pyrethroids to rats after direct injection into the central nervous system.

@article{Gray1982ToxicityOP,
  title={Toxicity of pyrethroids to rats after direct injection into the central nervous system.},
  author={Andrew J. Gray and John T. Rickard},
  journal={Neurotoxicology},
  year={1982},
  volume={3 1},
  pages={25-35}
}
The administration of very small doses of two synthetic pyrethroids, cismethrin and deltamethrin, into the lateral ventricles of the brain or the subarachnoid space around the spinal cord, produced signs of toxicity in rats that were similar to those observed after iv injection of much larger doses. Intraventricular injection of the radiolabeled pyrethroids demonstrated that the onset of toxicity corresponded to the radiolabel reaching a threshold level in the brain stem, cerebellum or upper… CONTINUE READING

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