Toxicity of nonsteroidal anti-inflammatory drugs. An overview of the epidemiological evidence.

@article{Carson1993ToxicityON,
  title={Toxicity of nonsteroidal anti-inflammatory drugs. An overview of the epidemiological evidence.},
  author={Jeffrey J L Carson and Laura Rees Willett},
  journal={Drugs},
  year={1993},
  volume={46 Suppl 1},
  pages={243-8}
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used throughout the world. This paper reviews the epidemiological data linking NSAID administration with gastrointestinal, hepatic, renal, haematological, and hypersensitivity reactions. Meta-analysis has demonstrated that NSAIDs are associated with serious upper gastrointestinal disorders, with a relative risk of 2.7 in patients receiving NSAIDs compared with subjects not receiving NSAIDs. An increase in the dose and duration of NSAIDs… CONTINUE READING
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