Toxicity of fungicides containing ethylene-bis-dithiocarbamate in serumless dissociated mesencephalic-striatal primary coculture

@article{Soleo1996ToxicityOF,
  title={Toxicity of fungicides containing ethylene-bis-dithiocarbamate in serumless dissociated mesencephalic-striatal primary coculture},
  author={Leonardo Soleo and Giovanni Defazio and Riccardo Scarselli and Roberto Zefferino and Paolo Livrea and Vito Fo{\`a}},
  journal={Archives of Toxicology},
  year={1996},
  volume={70},
  pages={678-682}
}
 Agricultural exposure to the organomanganese fungicide MANEB (manganese-ethylene-bis-dithiocarbamate) may induce an extrapyramidal syndrome resembling parkinsonism. To evaluate the relative role of manganese (Mn) and ethylene-bis-dithiocarbamate (EBDTC) in the hazard of organomanganese fungicides, we studied the effects of MANCOZEB (Mn-Zinc-EBDTC) and ZINEB (Zinc-EBDTC) on serumless dissociated mesencephalic-striatal primary coculture. High affinity 3H-dopamine (DA) and 14C GABA uptakes as… CONTINUE READING
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