Toxicity of fatty acids on ECV-304 endothelial cells.

  title={Toxicity of fatty acids on ECV-304 endothelial cells.},
  author={Laureane Nunes Masi and Erica Paula Portioli-Sanches and Thais Martins de Lima-Salgado and R. A. Curi},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  volume={25 8},
The effects of stearic (saturated) or oleic (monounsaturated) acids and their combination with ω-3 and ω-6 polyunsaturated fatty acids (PUFA) on death of endothelial cells (ECV-304 cell line) were investigated. We examined: loss of plasma membrane integrity, DNA fragmentation, accumulation of neutral lipids (NL) and release of reactive oxygen species (ROS). The fatty acids studied were: stearic (SA), oleic (OA), docosahexaenoic (DHA), eicosapentaenoic (EPA), linoleic (LA) and gamma-linolenic… CONTINUE READING