Toxicity of extended courses of linezolid: results of an Infectious Diseases Society of America Emerging Infections Network survey.

@article{Beekmann2008ToxicityOE,
  title={Toxicity of extended courses of linezolid: results of an Infectious Diseases Society of America Emerging Infections Network survey.},
  author={S. Beekmann and D. Gilbert and P. Polgreen},
  journal={Diagnostic microbiology and infectious disease},
  year={2008},
  volume={62 4},
  pages={
          407-10
        }
}
Since linezolid was licensed, rare-but-serious adverse events caused by inhibition of mitochondrial protein synthesis have been identified. These events may be more common when the drug is used longer than 28 days, which is the treatment length currently approved by the US Food and Drug Administration. The purpose of this study was to determine how often longer courses of linezolid are prescribed and the nature and relative frequency of adverse events associated with longer courses. Most of the… Expand
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