Toxicity of ethacrynic acid in isolated rat hepatocytes.

  title={Toxicity of ethacrynic acid in isolated rat hepatocytes.},
  author={Keisuke Yamamoto and Yasuhiro Masubuchi and Shizuo Narimatsu and Seiichi Kobayashi and Toshiharu Horie},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  volume={16 2},
Ethacrynic acid, a loop diuretic drug, caused lipid peroxidation in isolated rat hepatocytes. The thiobarbituric acid reactive substances (TBARS) formation showed a good correlation with the leakage of glutamic-oxaloacetic acid transaminase (GOT) from the hepatocytes. The addition of antioxidants such as N, N'-diphenyl-p-phenylenediamine (DPPD) and promethazine to the isolated rat hepatocyte suspension containing ethacrynic acid prevented the lipid peroxidation and decreased the GOT leakage to… CONTINUE READING
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