Toxicity of dieldrin for dopaminergic neurons in mesencephalic cultures.

  title={Toxicity of dieldrin for dopaminergic neurons in mesencephalic cultures.},
  author={Juan Zeno Sanchez-Ramos and Alicia G Facca and Abdul Basit and Sungmin Song},
  journal={Experimental neurology},
  volume={150 2},
Dieldrin can be retained for decades in lipid-rich tissue and has been measured in some postmortem PD brains. Dieldrin has been reported to deplete brain monoamines in several species and has been shown to inhibit mitochondrial respiration. To further investigate the possibility that it may be involved in the pathogenesis of parkinsonism, its toxicity for dopaminergic (DA) neurons was assessed in a mesencephalic cell culture model. Primary neuronal cultures of mesencephalic neurons were… CONTINUE READING


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