Toxicity of chloroacetaldehyde is similar in adult and pediatric kidney tubules


The nephrotoxicity of chloroacetaldehyde (CAA), one of the main products of hepatic ifosfamide metabolism, was compared in isolated human pediatric and adult renal tubules. Tubules metabolizing lactate were incubated in the presence of various concentrations of CAA (0.1–0.5 mM). Both at low, clinically relevant (0.2 mM), and at higher concentrations (0.3, 0… (More)
DOI: 10.1007/s00467-001-0765-2


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