Toxicity of cadmium in the perfused human placenta.

  title={Toxicity of cadmium in the perfused human placenta.},
  author={P J Wier and Richard K. Miller and Dev Maulik and P A diSant'Agnese},
  journal={Toxicology and applied pharmacology},
  volume={105 1},
Cadmium, a placental toxicant in rodents, was studied in the in vitro isolated dually perfused human placental lobule for periods of up to 12 hr to determine if cadmium can also be toxic in the human placenta. Placental lobules were perfused with a modified M199 medium containing 0, 10, 20, or 100 nmol of cadmium chloride/ml added only initially to the maternal perfusate. Every 4 hr, the perfusates in both the maternal and the fetal circuits were replaced with fresh perfusate containing no Cd… CONTINUE READING