Toxicity of amphetamines: an update

@article{Carvalho2012ToxicityOA,
  title={Toxicity of amphetamines: an update},
  author={M{\'a}rcia Carvalho and Helena Carmo and Vera Marisa Costa and Jo{\~a}o Paulo Capela and Helena Pontes and Fernando Remi{\~a}o and F{\'e}lix Carvalho and Maria de Lourdes Bastos},
  journal={Archives of Toxicology},
  year={2012},
  volume={86},
  pages={1167-1231}
}
Amphetamines represent a class of psychotropic compounds, widely abused for their stimulant, euphoric, anorectic, and, in some cases, emphathogenic, entactogenic, and hallucinogenic properties. These compounds derive from the β-phenylethylamine core structure and are kinetically and dynamically characterized by easily crossing the blood–brain barrier, to resist brain biotransformation and to release monoamine neurotransmitters from nerve endings. Although amphetamines are widely acknowledged as… Expand
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References

SHOWING 1-10 OF 611 REFERENCES
Mechanisms of neurotransmitter release by amphetamines: A review
TLDR
Current issues on the two apparent primary mechanisms--the redistribution of catecholamines from synaptic vesicles to the cytosol, and induction of reverse transport of transmitter through plasma membrane uptake carriers are reviewed. Expand
The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
TLDR
Evidence for the occurrence of MDMA-induced neurotoxic damage in human users remains equivocal, although some biochemical and functional data suggest that damage may occur in the brains of heavy users. Expand
Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.
  • C. J. Schmidt
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1987
TLDR
The neurochemical effects of the unique psychedelic agent, methylenedioxymethamphetamine (MDMA), indicate it may be a serotonergic neurotoxin related to agents such as p-chloroamphetamine and could be partially blocked by the uptake inhibitor as long as 6 hr after drug administration. Expand
Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition.
TLDR
The impact of CYP2D6 pharmacogenetics on acute toxicity is limited and one of the interesting features of MDMA metabolism is its potential involvement in the development of mid- to long-term neurotoxic effects as a result of progressive neurodegeneration of the serotonergic neurotransmission system. Expand
3,4-Methylenedioxy analogues of amphetamine: Defining the risks to humans
TLDR
This review examines the relevant human and animal literature to delineate the possible risks MDMA, MDA and MDE engender with oral consumption in humans and discusses toxicity, psychopathology, neurotoxicity, abuse potential and the potential for drug-drug interactions associated with acute and chronic use. Expand
Amphetamine toxicities
TLDR
Overall, multiple mechanisms are involved and interact to promote neurotoxicity to methamphetamine and MDMA and the high coincidence of substituted amphetamine abuse by humans with HIV and/or chronic stress exposure suggests a potential enhanced vulnerability of these individuals to the neurotoxic actions of the amphetamines. Expand
Amphetamines as Potential Inducers of Fatalities: A review in the district of Ghent from 1976-2004
TLDR
Although amphetamines-related fatalities are only a fraction of the total number of fatalities studied at the Department, their contribution to current forensic practice has been increasing during the last few years and it is strongly advisable to interpret the anatomo-pathological findings and the toxicological results together in arriving at a conclusion. Expand
Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview
TLDR
The main aim of this review was to contribute to the understanding of the cellular and molecular mechanisms involved in MDMA neurotoxicity, which can help in the development of therapeutic approaches to prevent or treat the long-term neuropsychiatric complications of MDMA abuse in humans. Expand
Sub-chronic nandrolone treatment modifies neurochemical and behavioral effects of amphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in rats
TLDR
The results of this study show that AAS-pre-treatment is able to modulate the reward-related neurochemical and behavioral effects of amphetamine and MDMA. Expand
Methamphetamine‐induced Neurotoxicity: Structure Activity Relationships
TLDR
Structural similarities among amphetamine analogs which have been demonstrated to have effects consistent with neurotoxic activity are discussed, as well as some common neuropharmacological actions which may be related to druginduced neurotoxic effects. Expand
...
1
2
3
4
5
...