Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.

@article{Butenhoff2002ToxicityOA,
  title={Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.},
  author={John L. Butenhoff and Giovanni Costa and Cliff R Elcombe and David Farrar and Kristin Elisa Ruud Hansen and Hiroyuki Iwai and Reinhard Jung and Gerald L. Kennedy and Paul H Lieder and Geary W. Olsen and Peter J Thomford},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={69 1},
  pages={
          244-57
        }
}
Ammonium perfluorooctanoate (APFO) is a processing aid in the production of fluoropolymers that has been shown to have a long half-life in human blood. To understand the potential toxicological response of primates, groups of male cynomolgus monkeys were given daily po (capsule) doses of either 0, 3, 10, or 30 (reduced to 20) mg/kg/day for 26 weeks. Two monkeys from each of the control and 10 mg/kg/day dose groups were observed for 90 days after the last dose. Clinical observations, clinical… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 131 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 70 extracted citations

Derivation of a drinking water equivalent level (DWEL) related to the maximum contaminant level goal for perfluorooctanoic acid (PFOA), a persistent water soluble compound.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2009
View 13 Excerpts
Highly Influenced

Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA)

Toxicological sciences : an official journal of the Society of Toxicology • 2018
View 5 Excerpts
Highly Influenced

Perfluoroalkylated substances : PFOA , PFOS and PFOSA

Poul Larsen, Estelle Giovalle
2015
View 8 Excerpts
Method Support
Highly Influenced

Characterization of risk for general population exposure to perfluorooctanoate.

Regulatory toxicology and pharmacology : RTP • 2004
View 9 Excerpts
Highly Influenced

Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate.

Toxicological sciences : an official journal of the Society of Toxicology • 2008
View 3 Excerpts
Highly Influenced

132 Citations

051015'02'05'09'13'17
Citations per Year
Semantic Scholar estimates that this publication has 132 citations based on the available data.

See our FAQ for additional information.