Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages.

@article{Futamura1996ToxicityOA,
  title={Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages.},
  author={Yushi Futamura},
  journal={The Journal of toxicological sciences},
  year={1996},
  volume={21 4},
  pages={253-67}
}
This study was designed to specify the toxicity of amiodarone toward mouse pulmonary endothelial cells in comparison with that of another cationic amphiphilic drug, i.e., mianserin. These examinations were performed in the absence and presence of mouse alveolar macrophages under transmembrane co-culture or in direct contact with the endothelial cells to assess the contribution of macrophages to the toxicities toward the endothelial cells. As a result of 24-hr treatment, amiodarone caused a… CONTINUE READING