Toxicity of amiodarone and amiodarone analogues on isolated rat liver mitochondria.

@article{Spaniol2001ToxicityOA,
  title={Toxicity of amiodarone and amiodarone analogues on isolated rat liver mitochondria.},
  author={Markus Spaniol and R. Bracher and Huy Riem Ha and Ferenc Follath and Stephan Kr{\"a}henb{\"u}hl},
  journal={Journal of hepatology},
  year={2001},
  volume={35 5},
  pages={628-36}
}
BACKGROUND Amiodarone is a well-known mitochondrial toxin consisting of a benzofuran ring (ring A) coupled to a p-OH-benzene structure substituted with 2 iodines and a diethyl-ethanolamine side chain (ring B). AIM To find out which part of amiodarone is responsible for mitochondrial toxicity. METHODS Amiodarone, ring A and B without the ethanolamine side-chain and iodines (B0), ring A and B with iodines but no ethanolamine (B2), ring B with 1 iodine and no ethanolamine (C1) and ring B with… CONTINUE READING
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