Toxicity of ZnO nanoparticles to macrophages due to cell uptake and intracellular release of zinc ions.

  title={Toxicity of ZnO nanoparticles to macrophages due to cell uptake and intracellular release of zinc ions.},
  author={Bing Wang and Yuying Zhang and Zhengwei Mao and Dahai Dr Yu and Changyou Gao},
  journal={Journal of nanoscience and nanotechnology},
  volume={14 8},
  • B. Wang, Yuying Zhang, +2 authors C. Gao
  • Published 1 August 2014
  • Medicine, Materials Science
  • Journal of nanoscience and nanotechnology
Although the ZnO nanoparticles (NPs) have been widely used in research and industry, their health risks are only concerned very recently. In this paper, attention is paid to elucidate the toxic effects and intrinsic mechanism of ZnO NPs to RAW 246.7 macrophage cells. The ZnO NPs from industry additives had a diameter of ~37 nm in a dry state and aggregated to submicron size in cell culture medium with slightly negative surface charge. Influences of ZnO NPs on cell toxicity and functions were… 
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