Toxicity of Jatropha curcas phorbol esters in mice.

  title={Toxicity of Jatropha curcas phorbol esters in mice.},
  author={Cai-yan Li and Rakshit K Devappa and Jianxin Liu and Jian-Min Lv and Harinder P. S. Makkar and Klaus M Becker},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={48 2},
Phorbol esters are the main toxins in Jatropha curcas seed and oil. The aim of this study was to assess the acute toxicity of phorbol esters given by intragastric administration and to determine the LD50 for Swiss Hauschka mice. The LD50 and 95% confidence limits for male mice were 27.34 mg/kg body mass and 24.90-29.89 mg/kg body mass; and the LD5 and LD95 were 18.87 and 39.62 mg/kg body mass, respectively. The regression equations between the probits of mortalities (Y) and the log of doses (D… CONTINUE READING


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