Toxicity of Glutathione-Binding Metals: A Review of Targets and Mechanisms

@inproceedings{Rubino2015ToxicityOG,
  title={Toxicity of Glutathione-Binding Metals: A Review of Targets and Mechanisms},
  author={Federico Maria Rubino},
  booktitle={Toxics},
  year={2015}
}
Mercury, cadmium, arsenic and lead are among priority metals for toxicological studies due to the frequent human exposure and to the significant burden of disease following acute and chronic intoxication. Among their common characteristics is chemical affinity to proteins and non-protein thiols and their ability to generate cellular oxidative stress by the best-known Fenton mechanism. Their health effects are however diverse: kidney and liver damage, cancer at specific sites, irreversible… CONTINUE READING
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