Toxicity of Dangerous Prey: Variation of Tetrodotoxin Levels Within and Among Populations of the Newt Taricha granulosa

@article{Hanifin2004ToxicityOD,
  title={Toxicity of Dangerous Prey: Variation of Tetrodotoxin Levels Within and Among Populations of the Newt Taricha granulosa},
  author={C. Hanifin and M. Yotsu-Yamashita and T. Yasumoto and E. Brodie and E. D. Brodie},
  journal={Journal of Chemical Ecology},
  year={2004},
  volume={25},
  pages={2161-2175}
}
The ability to identify and accurately measure traits at the phenotypic interface of potential coevolutionary interactions is critical in documenting reciprocal evolutionary change between species. We quantify the defensive chemical trait of a prey species, the newt Taricha granulosa, thought to be part of a coevolutionary arms race. Variation in newt toxicity among populations results from variation in levels of the neurotoxin tetrodotoxin (TTX). Individual variation in TTX levels occurs… Expand

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References

SHOWING 1-10 OF 59 REFERENCES
TETRODOTOXIN RESISTANCE IN GARTER SNAKES: AN EVOLUTIONARY RESPONSE OF PREDATORS TO DANGEROUS PREY
  • E. Brodie, E. Brodie
  • Biology, Medicine
  • Evolution; international journal of organic evolution
  • 1990
TLDR
Evidence that the garter snake Thamnophis sirtalis has evolved resistance to tetrodotoxin (TTX) in response to the toxicity of the newt Taricha granulosa is presented and results suggest that the predator‐prey arms race analogy may be applicable to this system. Expand
The occurrence of tetrodotoxin (tarichatoxin) in amphibia and the distribution of the toxin in the organs of newts (taricha).
TLDR
Tetrodotoxin is concentrated in the skin, ovaries and ova, muscle and blood and is present in trace amounts in the liver, viscera and testes in adult Taricha torosa. Expand
Chemical and Etiological Studies on Tetrodotoxin and Its Analogs
TLDR
Bacteria were found to be the genetic origin of TT, and the occurrence of new TTX analogs in pufferfish, newts and a frog revealed valuable information on biosynthetic as well as metabolic pathways of TTX and on structure-activity relationship. Expand
Absence of tetrodotoxins in a captive-raised riparian frog, Atelopus varius.
TLDR
The results strongly implicate environmental factors, perhaps symbiotic microorganisms, in the genesis of tetrodotoxins in the skin of frogs of the genus Atelopus, while indicating that the frog itself produces the skin bufadienolides. Expand
Further report of the occurrence of tetrodotoxin in Atelopus species (family: Bufonidae).
In alcoholic extracts from museum samples of the toads Atelopus subornatus and A. peruensis tetrodotoxin and its analogues, 4-epitetrodotoxin and 4,9-anhydrotetrodotoxin were detected by fluorometricExpand
Chemical phenotype matching between a plant and its insect herbivore.
  • M. Berenbaum, A. Zangerl
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
TLDR
Comparisons of contemporary plant phenotype distributions with phenotypes of herbarium specimens collected 9-125 years ago from across a similar latitudinal gradient suggest that for at least one resistance trait-sphondin concentration-interactions with webworms have led to escalatory change. Expand
EVOLUTIONARY RESPONSE OF PREDATORS TO DANGEROUS PREY‐REDUCTION OF TOXICITY OF NEWTS AND RESISTANCE OF GARTER SNAKES IN ISLAND POPULATIONS
  • E. Brodie, E. Brodie
  • Biology, Medicine
  • Evolution; international journal of organic evolution
  • 1991
TLDR
This paper presents the results of a major study of cross-breeding between a female European brown bear and a male polar bear and the evolution of the polar bear in the Logzkim Zoo. Expand
Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish.
TLDR
Bacteria isolated from the skin of the pufferfish Fugu poecilonotus were screened for tetrodotoxin production and yielded 2-amino-6-hydroxymethyl-8-hydroxyquinazoline, the identity of which was confirmed, after methylation or trimethylsilylation, by HPLC, mass spectrometry and gas chromatography - mass spectromaetry. Expand
Apparent lack of tetrodotoxin biosynthesis in captured Taricha torosa and Taricha granulosa.
In order to explore the origin of the potent neurotoxin tetrodotoxin, feeding experiments were carried out using [2-14C]-acetate, [guanido-14C]-arginine, [ureido-14C]-citrulline and [14C (U)]-glucoseExpand
Distribution of tetrodotoxin, 6-epitetrodotoxin, and 11-deoxytetrodotoxin in newts.
TLDR
Tetrodotoxin was detected in all nine species of newts tested, 6-epitetRodotoxin in six species, and 11-deoxytetrodOToxin in five species, thus suggesting that the analogues were common metabolites among newts. Expand
...
1
2
3
4
5
...