Toxicity of 5-fluorouracil for aerobic and hypoxic cells in two murine tumours

@article{Tannock1987ToxicityO5,
  title={Toxicity of 5-fluorouracil for aerobic and hypoxic cells in two murine tumours},
  author={Ian F. Tannock},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1987},
  volume={19},
  pages={53-56}
}
Chronically hypoxic cells in solid tumours are reported to be more slowly proliferating than aerobic cells situated closer to blood vessels. Cycle-active drugs such as 5-fluorouracil (5-FU) might be expected to have greater activity against rapidly proliferating aerobic cells. The effect of 5-FU was therefore assessed against aerobic and hypoxic cells in murine tumours; this was done by giving the drug alone or 1 h before irradiation of the tumour under aerobic or hypoxic conditions. Aerobic… CONTINUE READING

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