Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility.

@article{Michel1990ToxicityO1,
  title={Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility.},
  author={Patrick P Michel and B K Dandapani and Beat Knusel and Juan Sanchez-Ramos and Franz Hefti},
  journal={Journal of neurochemistry},
  year={1990},
  volume={54 4},
  pages={1102-9}
}
Cultures of dissociated embryonic rat mesencephalic cells were exposed to 10 microM 1-methyl-4-phenylpyridinium (MPP+), a concentration shown earlier to result in loss of greater than 85% of tyrosine hydroxylase (TH)-positive neurons without affecting the total number of cells observed by phase-contrast microscopy. To characterize better the selectivity of the toxic action of MPP+, other parameters were measured reflecting survival and function of dopaminergic or nondopaminergic neurons… CONTINUE READING

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