Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity

@article{Aramwit2015ToxicityEO,
  title={Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity},
  author={P. Aramwit and S. Porasuphatana and T. Srichana and T. Nakpheng},
  journal={Nanoscale Research Letters},
  year={2015},
  volume={10}
}
In the previous study, we have found that the cordycepin which was extracted from Cordyceps mycelia produced by growing Cordyceps militaris on the dead larva of Bombyx mori silkworms showed the anti-proliferative effect toward lung cancer cells without toxicity to non-cancer cells. In this work, the cordycepin was tested for its in vitro mutagenicity and in vivo toxicity. From the Ames test and subacute toxicity test using oral administration in a rat model, the cordycepin was proved to be a… Expand
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