Toxicity equivalence range design (TEQR): a practical Phase I design.

@article{Blanchard2011ToxicityER,
  title={Toxicity equivalence range design (TEQR): a practical Phase I design.},
  author={M. Suzette Blanchard and Jeffrey Longmate},
  journal={Contemporary clinical trials},
  year={2011},
  volume={32 1},
  pages={114-21}
}
PURPOSE This paper introduces the target equivalence range (TEQR) design, a frequentist implementation of the modified toxicity probability interval (mTPI) design, as a competitor to the standard 3+3 design (3+3). The 3+3 is the work horse design in Phase I. It is good at determining if a safe dose exits, but provides poor accuracy and precision in… CONTINUE READING