Toxicity antagonists in head and neck cancer.

  title={Toxicity antagonists in head and neck cancer.},
  author={Andy M. Trotti},
  journal={Seminars in radiation oncology},
  volume={8 4},
Clinical trials of altered fractionation and concurrent chemoradiation regimens have better elucidated the limits of both acute and late normal tissue toxicities in the head and neck. Acute effects on mucosal epithelium represent the principal barrier to intensification of radiation or chemoradiation schedules. Late soft tissue injury and organ dysfunction limit efforts to escalate radiation total dose. New insights into the cellular and molecular mechanisms of injury repair allow new… CONTINUE READING

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