Toxicity and kinetics of [3H]microcystin-LR in isolated perfused rat livers.

  title={Toxicity and kinetics of [3H]microcystin-LR in isolated perfused rat livers.},
  author={Judith G. Pace and N A Robinson and George A Miura and C F Matson and Thomas W. Geisbert and James D White},
  journal={Toxicology and applied pharmacology},
  volume={107 3},
Isolated rat livers were perfused for 60 min with either 0.3 or 0.5 microgram/ml (initial volume, 119 ml) of [3H]microcystin-LR at a constant flow of 10 ml/min in a recirculating system. During the 60-min exposure, toxin caused stimulation of glycogenolysis, liver engorgement, and cessation of bile flow. Electron micrographs of liver showed dilation of bile canaliculi and the space of Disse. loss of sinusoidal lining architecture, and decreased hepatocyte intercellular contacts. Although… CONTINUE READING

Similar Papers

Loading similar papers…