Toxicity and immunogenicity of purified Haemophilus ducreyi cytolethal distending toxin in a rabbit model.

@article{Wising2002ToxicityAI,
  title={Toxicity and immunogenicity of purified Haemophilus ducreyi cytolethal distending toxin in a rabbit model.},
  author={Catharina Wising and Liselott A Svensson and Hinda J Ahmed and Vivianne Sundaeus and Karin Ahlman and Ing-Marie Jonsson and Lena M{\"o}lne and Teresa Lagerg{\aa}rd},
  journal={Microbial pathogenesis},
  year={2002},
  volume={33 2},
  pages={
          49-62
        }
}
The cytolethal distending toxin of Haemophilus ducreyi (HdCDT) is a three-component toxin that induces the arrest of the mammalian cell cycle in the G2 phase. All of the individual gene products, CdtA, CdtB and CdtC, are required for toxic activity on cultured mammalian cells. The CdtB component alone exerts nuclease activity. The individual HdCDT components were purified by affinity chromatography or ion-exchange chromatography followed by gel-filtration. HdCDT was reconstituted and purified… CONTINUE READING
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