Toxicity and death following recreational use of 2-pyrrolidino valerophenone
@article{Eiden2013ToxicityAD, title={Toxicity and death following recreational use of 2-pyrrolidino valerophenone}, author={C{\'e}line Eiden and Olivier Mathieu and Philippe Cathala and Dani{\`e}le Debruyne and Eric Baccino and Pierre Petit and H{\'e}l{\`e}ne Peyri{\`e}re}, journal={Clinical Toxicology}, year={2013}, volume={51}, pages={899 - 903} }
Abstract Background. Consumption of substituted cathinones, frequently called ‘legal highs’ or ‘designer drugs’, is increasing in the European Union. In July 2012, the French Medicine Agency listed the substituted cathinone's chemical family as narcotic and psychotropic substances, to restrict their use and distribution. We present, here, the first documented cases of recreational use of 2-pyrrolidino valerophenone (PVP) associated with death for one patient, with post-mortem toxicological…
41 Citations
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References
SHOWING 1-10 OF 22 REFERENCES
Death Following Recreational Use of Designer Drug “Bath Salts” Containing 3,4-Methylenedioxypyrovalerone (MDPV)
- Medicine, PsychologyJournal of Medical Toxicology
- 2011
This is the first case in the medical literature to report death due to isolated confirmed MDPV intoxication, and the manner of death is also consistent with excited delirium syndrome.
Amphetamine-like effects in humans of the khat alkaloid cathinone.
- Biology, ChemistryBritish journal of clinical pharmacology
- 1990
The physical and mental changes that the subjects reported during the experiment indicated that cathinone has in humans euphorigenic and psychostimulant effects, and this alkaloid has also in humans amphetamine-like effects.
Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum, Methoxetamine, and Piperazines
- ChemistryJournal of Medical Toxicology
- 2011
The background, pharmacology, clinical effects, detection, and management of synthetic cannabinoid, synthetic cathinone, methoxetamine, and piperazine exposures are discussed.
New designer drug alpha-pyrrolidinovalerophenone (PVP): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques.
- Chemistry, BiologyJournal of mass spectrometry : JMS
- 2009
Nine different human cytochrome P450 isoenzymes in the side chain hydroxylation of PVP was investigated and CYP 2B6, 2C19, 2D6, and 3A4 were found to catalyze this reaction.
Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution and interpretation of results.
- MedicineJournal of analytical toxicology
- 2013
The highest MDPV concentration occurred in a suicide by hanging and the highest methylone concentration was in a driver, suggesting blood concentration does not appear to predict outcome regarding fatalities or impairment.
Psychoactive ‘Bath Salts’: Compounds, Mechanisms, and Toxicities
- BiologyNeuropsychopharmacology
- 2013
The unpublished findings show the drug is a potent blocker of dopamine and norepinephrine uptake, and the fact that synthetic cathinones enhance dopamine transmission predicts high abuse liability.
Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones.
- ChemistryDrug testing and analysis
- 2011
The preparation of brominated precursors carrying the 3,4-methylenedioxyphenyl nucleus revealed extensive α,α-dibromination: the mass spectral and NMR data of these intermediates are also presented and discussed.
A 9-state analysis of designer stimulant, "bath salt," hospital visits reported to poison control centers.
- MedicineAnnals of emergency medicine
- 2013
Detection and identification of pyrovalerone and its hydroxylated metabolite in the rat.
- Chemistry, BiologyJournal of analytical toxicology
- 1996
The two products, pyrovalerone and its metabolite, a hydroxylated product, were detected in rat urine up to 18 h after a single oral administration and are suggested as screening target compounds in dope analysis.
Energy-1 (‘NRG-1’): don't believe what the newspapers say about it being legal
- LawEmergency Medicine Journal
- 2011
Users of legal highs need to be aware that legal highs purchased over the internet may contain illegal substances and therefore they may be liable for prosecution if found in possession of these substances.