Toxicity and antitumor activity of cis-bis-carboxylato(trans-R,R-1,2-diaminocyclohexane) platinum(II) complexes entrapped in liposomes

@article{Knokhar1989ToxicityAA,
  title={Toxicity and antitumor activity of cis-bis-carboxylato(trans-R,R-1,2-diaminocyclohexane) platinum(II) complexes entrapped in liposomes},
  author={A. R. Knokhar and Salaam Al-Baker and Irwin H. Krakoff and R Perez-soler},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1989},
  volume={23},
  pages={219-224}
}
A new series of highly lipid-soluble cis-bis-carboxylato(trans-R,R-1,2-diaminocyclohexane)platinum(II) complexes were synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (IR), 195pt nuclear magnetic resonance (NMR)]. cis-bis-Neopentanoato(trans-R,R-1,2-diaminocyclohexane)platinum(II) (NPDP), cis-bis-neodecanoato(trans-R,R-1,2-diaminocyclohexane)-platinum(II) (NDDP), and cis-bis-n-decanoato(trans-R,R-1,2-diaminocyclohexane)platinum(II… CONTINUE READING

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