Corpus ID: 23552804

Toxicity and anticancer activity of a new triazine antifolate (NSC 127755).

@article{Corbett1982ToxicityAA,
  title={Toxicity and anticancer activity of a new triazine antifolate (NSC 127755).},
  author={T. Corbett and W. Leopold and D. Dykes and B. J. Roberts and D. Griswold and F. Schabel},
  journal={Cancer research},
  year={1982},
  volume={42 5},
  pages={
          1707-15
        }
}
A new triazine folate antagonist, 3-chloro-4-((4-(2-chloro-4-[4,6-diamino-2,2-dimethyl-s-triazin-1(2H)-yl]phenyl)butyl)) benzenesulfonyl fluoride compounded with ethanesulfonic acid (1:1) (NSC 127755), was highly active against four transplantable colon adenocarcinomas (36, 38, 10/A, 12/A) and the Dunning murine ovarian tumor M5076. Treatment schedule studies indicated that a prolonged time of exposure provided optimum antitumor activity for the compound. The combination of NSC 127755 plus 4… Expand
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  • Ts. H. Corbett, D. P. Griswold, B. J. Roberts, J. C. Peckham, F. M. Schabel
  • Medicine
  • Cancer
  • 1977
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