Toxicity Studies of Genetically Modified Plants: A Review of the Published Literature

@article{Domingo2007ToxicitySO,
  title={Toxicity Studies of Genetically Modified Plants: A Review of the Published Literature},
  author={Josep L. Domingo},
  journal={Critical Reviews in Food Science and Nutrition},
  year={2007},
  volume={47},
  pages={721 - 733}
}
  • J. L. Domingo
  • Published 2007
  • Biology, Medicine
  • Critical Reviews in Food Science and Nutrition
According to the information reported by the WHO, the genetically modified (GM) products that are currently on the international market have all passed risk assessments conducted by national authorities. [...] Key Method Studies about the safety of the potential use of potatoes, corn, soybeans, rice, cucumber, tomatoes, sweet pepper, peas, and canola plants for food and feed were included. The number of references was surprisingly limited. Moreover, most published studies were not performed by the biotechnology…Expand
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This study concluded that hepatorenal toxicities were possible, and that longer testing was necessary, and was criticized by the company developing the GMOs in question and the regulatory bodies. Expand
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References

SHOWING 1-10 OF 83 REFERENCES
[Health risks of genetically modified foods: a literature review].
TLDR
The main goal of this review has been to know which is the state-of-the art regarding to the potential adverse effects of GM foods. Expand
The safety of genetically modified foods produced through biotechnology.
TLDR
The SOT defines here its current consensus position on the safety of foods produced through biotechnology (genetic engineering), and supports the use of the substantial equivalence concept as part of the safety assessment of biotechnology-derived foods. Expand
In vivo experiments on the safety evaluation of GM components of feeds and foods
TLDR
The results of feeding experiments indicate that soyabean meal obtained from herbicide-tolerant lines and insect-resistant maize are substantially and nutritionally equivalent to their conventional lines. Expand
In Vivo Studies on Possible Health Consequences of Genetically Modified Food and Feed—with Particular Regard to Ingredients Consisting of Genetically Modified Plant Materials
TLDR
In this minireview the data made available in these published studies is discussed and the data consisting of genetically modified microorganisms or parts of animals/fish ingredients produced by/from genetically modified organisms is discussed. Expand
Potential Adverse Health Effects of Genetically Modified Crops
  • A. Bakshi
  • Biology, Medicine
  • Journal of toxicology and environmental health. Part B, Critical reviews
  • 2003
TLDR
The review of available literature indicates that the genetically modified crops available in the market that are intended for human consumption are generally safe; their consumption is not associated with serious health problems. Expand
Multigeneration reproductive and developmental toxicity study of bar gene inserted into genetically modified potato on rats.
  • G. Rhee, D. Cho, +9 authors K. Choi
  • Biology, Medicine
  • Journal of toxicology and environmental health. Part A
  • 2005
TLDR
It is suggested that genetically modified crops have no adverse effects on the multigeneration reproductive-developmental ability and a science-based risk assessment is needed in order to use GM crops as a conventional foodstuff. Expand
[Genetically modified foods. Advantages and human health risks].
One of the most important issue with which the mankind is confronting now is related to the quantitatively as well as qualitatively assurance of the food supply necessary for human species existence.Expand
Substantial equivalence--an appropriate paradigm for the safety assessment of genetically modified foods?
TLDR
New 'profiling' methods will allow for the screening of potential changes in the modified host organism at different integration levels, i.e. at the genome level, during gene expression and protein translation, and at the level of cellular metabolism. Expand
A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats.
  • Malene Schrøder, M. Poulsen, +11 authors I. Knudsen
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2007
TLDR
The results show no adverse or toxic effects of KMD1 rice when tested in the design used in this 90-day study, leading to the overall conclusion that safety assessment for unintended effects of a GM crop cannot be done without additional test groups. Expand
Are Genetically Modified Plants Useful and Safe?
  • J. Weil
  • Biology, Medicine
  • IUBMB life
  • 2005
TLDR
Possible risks for human health, the environment, or for the environment (such as the appearance of superweeds as a result from gene flow), should be carefully studied, and a science‐based assessment of benefits vs. risks should be made on a csae by case basis. Expand
...
1
2
3
4
5
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